GSTA3

GENE INFORMATION

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Gene name

GSTA3

Synonyms

Description

Glutathione S-transferase alpha 3 (HGNC Symbol)

Entrez gene summary

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p12.2

Chromosome location (bp)

52761437 - 52774483

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174156 (version 75.37)

Entrez gene

2940

UniProt

Q16772 (UniProt - Evidence at protein level)

neXtProt

NX_Q16772

Antibodypedia

GSTA3 antibodies
 

PROTEIN VIEW

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GSTA3-001
 
GSTA3-002
 
GSTA3-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GSTA3-001 ENSP00000399142
ENST00000431899
Show » Show » 108 12.5 No 0
GSTA3-002 ENSP00000360007
ENST00000370968
Q5JW85
Show all »
Show » Show » 172 19.7 No 0
GSTA3-004 ENSP00000211122
ENST00000211122
Q16772
Show all »
Show » Show » 222 25.3 No 0