TNK1

GENE INFORMATION

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Gene name

TNK1

Synonyms

Description

Tyrosine kinase, non-receptor, 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

17

Cytoband

p13.1

Chromosome location (bp)

7283853 - 7293093

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000174292 (version 75.37)

Entrez gene

8711

UniProt

Q13470 (UniProt - Evidence at protein level)

neXtProt

NX_Q13470

Antibodypedia

TNK1 antibodies
 

PROTEIN VIEW

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TNK1-001
 
TNK1-002
 
TNK1-007
 
TNK1-008
 
TNK1-009
 
TNK1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNK1-001 ENSP00000459799
ENST00000576812
Q13470
Show all »
Show » Show » 666 72.5 No 0
TNK1-002 ENSP00000458834
ENST00000570896
Q13470
Show all »
Show » Show » 661 71.9 No 0
TNK1-007 ENSP00000460146
ENST00000576716
I3L334
Show all »
Show » 84 9.3 No 0
TNK1-008 ENSP00000466590
ENST00000577009
Show » 3 0.3 No 0
TNK1-009 ENSP00000475164
ENST00000576207
U3KPR9
Show all »
Show » 77 8.8 No 0
TNK1-201 ENSP00000312309
ENST00000311668
Q13470
Show all »
Show » Show » 661 71.9 No 0