UBE2C - Gene info - The Human Protein Atlas

Gene name

UBE2C (HGNC Symbol)

Synonyms

UBCH10

Description

Ubiquitin-conjugating enzyme E2C (HGNC Symbol)

Entrez gene summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Chromosome

Cytoband

q13.12

Chromosome location (bp)

44441215 - 44445596

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175063 (version 75.37)

Entrez gene

11065

UniProt

O00762 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2C-001

ENSP00000348838
ENST00000356455

O00762
Show all » « Hide

O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C
Q5TZN3 [Target identity:100%; Query identity:100%]
UBE2C protein; Ubiquitin-conjugating enzyme E2C; Ubiquitin-conjugating enzyme E2C, isoform CRA_e

Show » « Hide

   Ligase
Enzymes
   ENZYME proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008054 [cyclin catabolic process]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0016567 [protein ubiquitination]
GO:0016881 [acid-amino acid ligase activity]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031536 [positive regulation of exit from mitosis]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]

179

19.7

UBE2C-003

ENSP00000335674
ENST00000335046

O00762
Show all » « Hide

O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C

Show » « Hide

   Ligase
Enzymes
   ENZYME proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000278 [mitotic cell cycle]
GO:0004842 [ubiquitin-protein ligase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005680 [anaphase-promoting complex]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0007049 [cell cycle]
GO:0007051 [spindle organization]
GO:0007094 [mitotic spindle assembly checkpoint]
GO:0008054 [cyclin catabolic process]
GO:0010458 [exit from mitosis]
GO:0010994 [free ubiquitin chain polymerization]
GO:0016567 [protein ubiquitination]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031536 [positive regulation of exit from mitosis]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0051436 [negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051437 [positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051439 [regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle]
GO:0051488 [activation of anaphase-promoting complex activity]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]

161

17.4

UBE2C-004

ENSP00000361649
ENST00000372568

O00762
Show all » « Hide

O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C

Show » « Hide

   Ligase
Enzymes
   ENZYME proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

140

15.8

UBE2C-005

ENSP00000243893
ENST00000243893

K4DI81
Show all » « Hide

K4DI81 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2 C; Ubiquitin-conjugating enzyme E2C, isoform CRA_d

Show » « Hide

Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

5.1

UBE2C-006

ENSP00000333975
ENST00000352551

O00762
Show all » « Hide

O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C

Show » « Hide

   Ligase
Enzymes
   ENZYME proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

150

16.7

UBE2C-201

ENSP00000385878
ENST00000405520

O00762
Show all » « Hide

O00762 [Direct mapping]
Ubiquitin-conjugating enzyme E2 C

Show » « Hide

   Ligase
Enzymes
   ENZYME proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

140

15.8

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.