RAG2

GENE INFORMATION

? »

Gene name

RAG2

Synonyms

Description

Recombination activating gene 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p12

Chromosome location (bp)

36597124 - 36619829

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175097 (version 75.37)

Entrez gene

5897

UniProt

P55895 (UniProt - Evidence at protein level)

neXtProt

NX_P55895

Antibodypedia

RAG2 antibodies
 

PROTEIN VIEW

? »
 
 
 
RAG2-001
 
RAG2-003
 
RAG2-004
 
RAG2-008
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAG2-001 ENSP00000308620
ENST00000311485
P55895
Show all »
Show » Show » 527 59.2 No 0
RAG2-003 ENSP00000436895
ENST00000527033
E9PQB9
Show all »
Show » Show » 71 8 No 0
RAG2-004 ENSP00000432174
ENST00000532616
Show » 1 0.1 No 0
RAG2-008 ENSP00000436327
ENST00000529083
E9PPU5
Show all »
Show » Show » 150 17 No 0