PSMD2

GENE INFORMATION

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Gene name

PSMD2 (HGNC Symbol)

Synonyms

MGC14274, P97, Rpn1, S2, TRAP2

Description

Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 (HGNC Symbol)

Entrez gene summary

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

3

Cytoband

q27.1

Chromosome location (bp)

184016497 - 184026842

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175166 (version 75.37)

Entrez gene

5708

UniProt

Q13200 (UniProt - Evidence at protein level)

neXtProt

NX_Q13200

Antibodypedia

PSMD2 antibodies
 

PROTEIN VIEW

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PSMD2-001
 
PSMD2-002
 
PSMD2-003
 
PSMD2-004
 
PSMD2-008
 
PSMD2-010
 
PSMD2-017
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSMD2-001 ENSP00000310129
ENST00000310118
Q13200
Show all »
Show » Show » 908 100.2 No 1
PSMD2-002 ENSP00000402618
ENST00000435761
E9PCS3
Show all »
Show » Show » 749 82.2 No 1
PSMD2-003 ENSP00000416028
ENST00000439383
E7EW34
Show all »
Show » Show » 778 85.6 No 1
PSMD2-004 ENSP00000414061
ENST00000417952
C9JPC0
Show all »
Show » Show » 217 24.6 No 0
PSMD2-008 ENSP00000411494
ENST00000433010
F8WBS8
Show all »
Show » 59 6.6 No 0
PSMD2-010 ENSP00000407259
ENST00000445558
Show » 143 16.4 No 0
PSMD2-017 ENSP00000400330
ENST00000432855
Show » Show » 203 22.3 No 0