UCP3

GENE INFORMATION

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Gene name

UCP3 (HGNC Symbol)

Synonyms

SLC25A9

Description

Uncoupling protein 3 (mitochondrial, proton carrier) (HGNC Symbol)

Entrez gene summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.[provided by RefSeq, Nov 2008]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

73711326 - 73720480

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175564 (version 75.37)

Entrez gene

7352

UniProt

P55916 (UniProt - Evidence at protein level)

neXtProt

NX_P55916

Antibodypedia

UCP3 antibodies
 

PROTEIN VIEW

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UCP3-001
 
UCP3-004
 
UCP3-005
 
UCP3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UCP3-001 ENSP00000323740
ENST00000314032
P55916
Show all »
Show » Show » 312 34.2 No 0
UCP3-004 ENSP00000392143
ENST00000426995
P55916
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Show » Show » 275 29.8 No 0
UCP3-005 ENSP00000445279
ENST00000544614
F5H3N5
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Show » Show » 96 10.3 No 0
UCP3-201 ENSP00000343615
ENST00000348534
C9JJ98
Show all »
Show » Show » 210 23 No 0