UCP2

GENE INFORMATION

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Gene name

UCP2 (HGNC Symbol)

Synonyms

SLC25A8

Description

Uncoupling protein 2 (mitochondrial, proton carrier) (HGNC Symbol)

Entrez gene summary

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q13.4

Chromosome location (bp)

73685712 - 73694352

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000175567 (version 75.37)

Entrez gene

7351

UniProt

P55851 (UniProt - Evidence at protein level)

neXtProt

NX_P55851

Antibodypedia

UCP2 antibodies
 

PROTEIN VIEW

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UCP2-001
 
UCP2-002
 
UCP2-007
 
UCP2-008
 
UCP2-010
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UCP2-001 ENSP00000312029
ENST00000310473
P55851
Show all »
Show » Show » 309 33.2 No 0
UCP2-002 ENSP00000441147
ENST00000536983
F5GX45
Show all »
Show » Show » 225 23.9 No 0
UCP2-007 ENSP00000438230
ENST00000539764
F5H312
Show all »
Show » 33 3.3 No 0
UCP2-008 ENSP00000439951
ENST00000544615
H0YFR8
Show all »
Show » Show » 282 30.5 No 0
UCP2-010 ENSP00000439706
ENST00000545212
H0YFQ0
Show all »
Show » Show » 130 13.7 No 0