CIDEA

GENE INFORMATION

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Gene name

CIDEA (HGNC Symbol)

Synonyms

CIDE-A

Description

Cell death-inducing DFFA-like effector a (HGNC Symbol)

Entrez gene summary

This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified. [provided by RefSeq, Aug 2010]

Chromosome

18

Cytoband

p11.21

Chromosome location (bp)

12254318 - 12277594

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176194 (version 75.37)

Entrez gene

1149

UniProt

O60543 (UniProt - Evidence at protein level)

neXtProt

NX_O60543

Antibodypedia

CIDEA antibodies
 

PROTEIN VIEW

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CIDEA-002
 
CIDEA-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CIDEA-002 ENSP00000320209
ENST00000320477
O60543
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Show » Show » 219 24.7 No 0
CIDEA-003 ENSP00000429238
ENST00000522713
E5RJ03
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Show » 200 21.3 No 0