HSD11B2

GENE INFORMATION

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Gene name

HSD11B2 (HGNC Symbol)

Synonyms

SDR9C3

Description

Hydroxysteroid (11-beta) dehydrogenase 2 (HGNC Symbol)

Entrez gene summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

Chromosome

16

Cytoband

q22.1

Chromosome location (bp)

67464555 - 67471456

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176387 (version 75.37)

Entrez gene

3291

UniProt

P80365 (UniProt - Evidence at protein level)

neXtProt

NX_P80365

Antibodypedia

HSD11B2 antibodies
 

PROTEIN VIEW

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HSD11B2-001
 
HSD11B2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSD11B2-001 ENSP00000316786
ENST00000326152
P80365
Show all »
Show » Show » 405 44.1 No 1
HSD11B2-003 ENSP00000473429
ENST00000566606
R4GN04
Show all »
Show » 58 6.3 No 1