SHMT1

GENE INFORMATION

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Gene name

SHMT1 (HGNC Symbol)

Synonyms

CSHMT, MGC15229, MGC24556, SHMT

Description

Serine hydroxymethyltransferase 1 (soluble) (HGNC Symbol)

Entrez gene summary

This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

17

Cytoband

p11.2

Chromosome location (bp)

18231187 - 18266856

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000176974 (version 75.37)

Entrez gene

6470

UniProt

P34896 (UniProt - Evidence at protein level)

neXtProt

NX_P34896

Antibodypedia

SHMT1 antibodies
 

PROTEIN VIEW

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SHMT1-001
 
SHMT1-003
 
SHMT1-006
 
SHMT1-007
 
SHMT1-009
 
SHMT1-201
 
SHMT1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SHMT1-001 ENSP00000318868
ENST00000316694
P34896
Show all »
Show » Show » 483 53.1 No 0
SHMT1-003 ENSP00000318805
ENST00000354098
P34896
Show all »
Show » Show » 444 49 No 0
SHMT1-006 ENSP00000462043
ENST00000580002
J3KRK5
Show all »
Show » Show » 128 14.2 No 0
SHMT1-007 ENSP00000462041
ENST00000583780
Show » 1 0.1 No 0
SHMT1-009 ENSP00000462227
ENST00000582653
J3KRZ5
Show all »
Show » Show » 167 18.6 No 0
SHMT1-201 ENSP00000345881
ENST00000352886
P34896
Show all »
Show » Show » 403 44.6 No 0
SHMT1-202 ENSP00000440089
ENST00000539052
B4DPM9
Show all »
Show » Show » 345 37.7 No 0