TGIF1 - Gene info - The Human Protein Atlas

TGIF1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	TGIF1 (HGNC Symbol)
Synonyms	HPE4, TGIF
Description	TGFB-induced factor homeobox 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Chromosome	18
Cytoband	p11.31
Chromosome location (bp)	3411606 - 3458409
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000177426 (version 75.37)
Entrez gene	7050
UniProt	Q15583 (UniProt - Evidence at protein level)
neXtProt	NX_Q15583
Antibodypedia	TGIF1 antibodies

PROTEIN VIEW

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TGIF1-001		TGIF1-002		TGIF1-003		TGIF1-004		TGIF1-005		TGIF1-006		TGIF1-007		TGIF1-008		TGIF1-010		TGIF1-011		TGIF1-012		TGIF1-015		TGIF1-016		TGIF1-017		TGIF1-018		TGIF1-019		TGIF1-021		TGIF1-201		TGIF1-202		TGIF1-203

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
TGIF1-001	ENSP00000447747 ENST00000548489	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:76%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:58%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:48%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:46%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:45%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:32%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	286	31.1	No
TGIF1-002	ENSP00000339631 ENST00000343820	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:90%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:80%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:61%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:50%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:48%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:48%; Query identity:100%] Homeobox protein TGIF1 F8VYL4 [Target identity:43%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:33%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	272	29.7	No
TGIF1-003	ENSP00000327959 ENST00000330513	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:61%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:41%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:34%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:33%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:32%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:22%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0010629 [negative regulation of gene expression] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	401	43	No
TGIF1-004	ENSP00000449501 ENST00000472042	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:97%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:52%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:51%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:36%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	252	27.7	No
TGIF1-005	ENSP00000448934 ENST00000546979	F8VYL4 Show all » « Hide F8VYL4 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:77%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	118	13.4	No
TGIF1-006	ENSP00000384133 ENST00000407501	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:90%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:80%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:61%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:50%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:48%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:48%; Query identity:100%] Homeobox protein TGIF1 F8VYL4 [Target identity:43%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:33%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	272	29.7	No
TGIF1-007	ENSP00000446944 ENST00000551402	F8W1J9 Show all » « Hide F8W1J9 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0043565 [sequence-specific DNA binding]	132	15	No
TGIF1-008	ENSP00000449287 ENST00000552383	F8VWK5 Show all » « Hide F8VWK5 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:82%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:79%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:77%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	168	18.7	No
TGIF1-010	ENSP00000449531 ENST00000550958	F8VW34 Show all » « Hide F8VW34 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:70%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	131	14.9	No
TGIF1-011	ENSP00000448121 ENST00000549780	F8VUY0 Show all » « Hide F8VUY0 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:76%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:63%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:60%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:59%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:42%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	219	24.1	No
TGIF1-012	ENSP00000449973 ENST00000549253	F8VXG3 Show all » « Hide F8VXG3 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	92	10.8	No
TGIF1-015	ENSP00000450025 ENST00000551541	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:97%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:52%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:51%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:36%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	252	27.7	No
TGIF1-016	ENSP00000343969 ENST00000345133	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:97%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:52%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:51%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:36%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	252	27.7	No
TGIF1-017	ENSP00000449580 ENST00000549546	F8VVS9 Show all » « Hide F8VVS9 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:89%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:68%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:56%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:53%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:37%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	246	27.1	No
TGIF1-018	ENSP00000449722 ENST00000549468	F8VX54 Show all » « Hide F8VX54 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:98%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:69%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	133	15.1	No
TGIF1-019	ENSP00000446838 ENST00000551333	F8VZH2 Show all » « Hide F8VZH2 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:96%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:94%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	138	15.6	No
TGIF1-021	ENSP00000462285 ENST00000577543	J3KS32 Show all » « Hide J3KS32 [Target identity:100%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0043565 [sequence-specific DNA binding]	84	9.4	No
TGIF1-201	ENSP00000383031 ENST00000400167	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:97%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:52%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:51%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:36%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	252	27.7	No
TGIF1-202	ENSP00000385206 ENST00000401449	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:97%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:52%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:51%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:36%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	252	27.7	No
TGIF1-203	ENSP00000384970 ENST00000405385	Q15583 Show all » « Hide Q15583 [Direct mapping] Homeobox protein TGIF1 F8VVS9 [Target identity:97%; Query identity:100%] Homeobox protein TGIF1 F8VUY0 [Target identity:86%; Query identity:100%] Homeobox protein TGIF1 F8VWK5 [Target identity:66%; Query identity:100%] Homeobox protein TGIF1 F8VZH2 [Target identity:54%; Query identity:100%] Homeobox protein TGIF1 F8VX54 [Target identity:52%; Query identity:100%] Homeobox protein TGIF1 F8VW34 [Target identity:51%; Query identity:100%] Homeobox protein TGIF1 F8VXG3 [Target identity:36%; Query identity:100%] Homeobox protein TGIF1	Show » « Hide Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Disease related genes Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001843 [neural tube closure] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007275 [multicellular organismal development] GO:0007368 [determination of left/right symmetry] GO:0008285 [negative regulation of cell proliferation] GO:0009953 [dorsal/ventral pattern formation] GO:0010467 [gene expression] GO:0010470 [regulation of gastrulation] GO:0038092 [nodal signaling pathway] GO:0042493 [response to drug] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048146 [positive regulation of fibroblast proliferation] GO:0048387 [negative regulation of retinoic acid receptor signaling pathway] GO:0060041 [retina development in camera-type eye] GO:0070410 [co-SMAD binding] GO:0071363 [cellular response to growth factor stimulus]	252	27.7	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.