NRXN1 - Gene info - The Human Protein Atlas

NRXN1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NRXN1 (HGNC Symbol)
Synonyms	Hs.22998, KIAA0578
Description	Neurexin 1 (HGNC Symbol)
Entrez gene summary	Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]
Chromosome	2
Cytoband	p16.3
Chromosome location (bp)	50145643 - 51259674
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000179915 (version 75.37)
Entrez gene	9378
UniProt	P58400 (UniProt - Evidence at protein level), Q9ULB1 (UniProt - Evidence at transcript level)
neXtProt	NX_P58400, NX_Q9ULB1
Antibodypedia	NRXN1 antibodies

PROTEIN VIEW

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NRXN1-001		NRXN1-002		NRXN1-003		NRXN1-004		NRXN1-010		NRXN1-012		NRXN1-015		NRXN1-016		NRXN1-017		NRXN1-201		NRXN1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
NRXN1-001	ENSP00000384311 ENST00000406316	Q9ULB1 Show all » « Hide Q9ULB1 [Direct mapping] Neurexin-1 Q08AH0 [Target identity:13%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007411 [axon guidance] GO:0007416 [synapse assembly] GO:0007612 [learning] GO:0009986 [cell surface] GO:0030054 [cell junction] GO:0030198 [extracellular matrix organization] GO:0030534 [adult behavior] GO:0033130 [acetylcholine receptor binding] GO:0035176 [social behavior] GO:0042297 [vocal learning] GO:0042734 [presynaptic membrane] GO:0050839 [cell adhesion molecule binding] GO:0050885 [neuromuscular process controlling balance] GO:0051965 [positive regulation of synapse assembly] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060134 [prepulse inhibition] GO:0071625 [vocalization behavior] GO:0090129 [positive regulation of synapse maturation] GO:0097104 [postsynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097116 [gephyrin clustering] GO:0097118 [neuroligin clustering] GO:0097119 [postsynaptic density protein 95 clustering] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000821 [regulation of grooming behavior]	1477	161.9	Yes	1
NRXN1-002	ENSP00000385142 ENST00000404971	Q9ULB1 Show all » « Hide Q9ULB1 [Direct mapping] Neurexin-1 Q08AH0 [Target identity:12%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007411 [axon guidance] GO:0007416 [synapse assembly] GO:0007612 [learning] GO:0009986 [cell surface] GO:0030054 [cell junction] GO:0030198 [extracellular matrix organization] GO:0030534 [adult behavior] GO:0033130 [acetylcholine receptor binding] GO:0035176 [social behavior] GO:0042297 [vocal learning] GO:0042734 [presynaptic membrane] GO:0050839 [cell adhesion molecule binding] GO:0050885 [neuromuscular process controlling balance] GO:0051965 [positive regulation of synapse assembly] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060134 [prepulse inhibition] GO:0071625 [vocalization behavior] GO:0090129 [positive regulation of synapse maturation] GO:0097104 [postsynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097116 [gephyrin clustering] GO:0097118 [neuroligin clustering] GO:0097119 [postsynaptic density protein 95 clustering] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000821 [regulation of grooming behavior]	1547	169.9	Yes	1
NRXN1-003	ENSP00000385017 ENST00000401669	E7ERL8 Show all » « Hide E7ERL8 [Target identity:100%; Query identity:100%] Neurexin-1-beta Q08AH0 [Target identity:13%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral to membrane] GO:0051965 [positive regulation of synapse assembly] GO:0090129 [positive regulation of synapse maturation]	1507	165.4	Yes	1
NRXN1-004	ENSP00000385310 ENST00000405581	E7EQN4 Show all » « Hide E7EQN4 [Target identity:100%; Query identity:100%] Neurexin-1-beta	Show » « Hide MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	278	30.4	Yes	0
NRXN1-010	ENSP00000434015 ENST00000405472	Q9ULB1 Show all » « Hide Q9ULB1 [Direct mapping] Neurexin-1 A7E294 [Target identity:99%; Query identity:100%] NRXN1 protein Q08AH0 [Target identity:13%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004872 [receptor activity] GO:0005246 [calcium channel regulator activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral to plasma membrane] GO:0007155 [cell adhesion] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007411 [axon guidance] GO:0007416 [synapse assembly] GO:0007612 [learning] GO:0009986 [cell surface] GO:0030054 [cell junction] GO:0030198 [extracellular matrix organization] GO:0030534 [adult behavior] GO:0033130 [acetylcholine receptor binding] GO:0035176 [social behavior] GO:0042297 [vocal learning] GO:0042734 [presynaptic membrane] GO:0050839 [cell adhesion molecule binding] GO:0050885 [neuromuscular process controlling balance] GO:0051965 [positive regulation of synapse assembly] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0060134 [prepulse inhibition] GO:0071625 [vocalization behavior] GO:0090129 [positive regulation of synapse maturation] GO:0097104 [postsynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097116 [gephyrin clustering] GO:0097118 [neuroligin clustering] GO:0097119 [postsynaptic density protein 95 clustering] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential] GO:2000821 [regulation of grooming behavior]	1499	164.7	Yes	1
NRXN1-012	ENSP00000341184 ENST00000342183	P58400 Show all » « Hide P58400 [Direct mapping] Neurexin-1-beta Q08AH0 [Target identity:44%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0005102 [receptor binding] GO:0005246 [calcium channel regulator activity] GO:0005886 [plasma membrane] GO:0007157 [heterophilic cell-cell adhesion] GO:0007158 [neuron cell-cell adhesion] GO:0007268 [synaptic transmission] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0007612 [learning] GO:0009986 [cell surface] GO:0016021 [integral to membrane] GO:0016339 [calcium-dependent cell-cell adhesion] GO:0021707 [cerebellar granule cell differentiation] GO:0023041 [neuronal signal transduction] GO:0030054 [cell junction] GO:0030139 [endocytic vesicle] GO:0030534 [adult behavior] GO:0035176 [social behavior] GO:0035418 [protein localization to synapse] GO:0042734 [presynaptic membrane] GO:0044295 [axonal growth cone] GO:0045184 [establishment of protein localization] GO:0046872 [metal ion binding] GO:0048306 [calcium-dependent protein binding] GO:0050839 [cell adhesion molecule binding] GO:0051490 [negative regulation of filopodium assembly] GO:0051965 [positive regulation of synapse assembly] GO:0051968 [positive regulation of synaptic transmission, glutamatergic] GO:0071625 [vocalization behavior] GO:0090004 [positive regulation of establishment of protein localization to plasma membrane] GO:0090129 [positive regulation of synapse maturation] GO:0097091 [synaptic vesicle clustering] GO:0097104 [postsynaptic membrane assembly] GO:0097105 [presynaptic membrane assembly] GO:0097109 [neuroligin family protein binding] GO:0097112 [gamma-aminobutyric acid receptor clustering] GO:0097114 [N-methyl-D-aspartate receptor clustering] GO:0097116 [gephyrin clustering] GO:0097117 [guanylate kinase-associated protein clustering] GO:0097118 [neuroligin clustering] GO:0097119 [postsynaptic density protein 95 clustering] GO:0097120 [receptor localization to synapse] GO:2000310 [regulation of N-methyl-D-aspartate selective glutamate receptor activity] GO:2000311 [regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity] GO:2000463 [positive regulation of excitatory postsynaptic membrane potential]	442	46.9	No	1
NRXN1-015	ENSP00000385580 ENST00000401710	E7ETA5 Show all » « Hide E7ETA5 [Target identity:100%; Query identity:100%] Neurexin-1-beta Q08AH0 [Target identity:40%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral to membrane] GO:0051965 [positive regulation of synapse assembly] GO:0090129 [positive regulation of synapse maturation]	495	53.3	No	1
NRXN1-016	ENSP00000396738 ENST00000412315		Show » « Hide Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		210	22.8	No	1
NRXN1-017	ENSP00000367510 ENST00000378262		Show » « Hide Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		144	15.5	No	1
NRXN1-201	ENSP00000385434 ENST00000402717	F5GYC7 Show all » « Hide F5GYC7 [Target identity:100%; Query identity:100%] Neurexin-1-beta Q08AH0 [Target identity:13%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral to membrane] GO:0051965 [positive regulation of synapse assembly] GO:0090129 [positive regulation of synapse maturation]	1499	164.7	Yes	1
NRXN1-202	ENSP00000385681 ENST00000406859	F8WB18 Show all » « Hide F8WB18 [Target identity:100%; Query identity:100%] Neurexin-1-beta Q08AH0 [Target identity:13%; Query identity:100%] NRXN1 protein	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0007269 [neurotransmitter secretion] GO:0007416 [synapse assembly] GO:0016021 [integral to membrane] GO:0051965 [positive regulation of synapse assembly] GO:0090129 [positive regulation of synapse maturation]	1477	161.9	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.