GREM2

GENE INFORMATION

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Gene name

GREM2 (HGNC Symbol)

Synonyms

CKTSF1B2, DAND3, FLJ21195, Prdc

Description

Gremlin 2, DAN family BMP antagonist (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

q43

Chromosome location (bp)

240652873 - 240775449

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000180875 (version 75.37)

Entrez gene

64388

UniProt

Q9H772 (UniProt - Evidence at protein level)

neXtProt

NX_Q9H772

Antibodypedia

GREM2 antibodies
 

PROTEIN VIEW

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GREM2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GREM2-001 ENSP00000318650
ENST00000318160
Q9H772
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