PAPPA

GENE INFORMATION

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Gene name

PAPPA (HGNC Symbol)

Synonyms

ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1

Description

Pregnancy-associated plasma protein A, pappalysin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q33.1

Chromosome location (bp)

118916083 - 119164601

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000182752 (version 75.37)

Entrez gene

5069

UniProt

Q13219 (UniProt - Evidence at protein level)

neXtProt

NX_Q13219

Antibodypedia

PAPPA antibodies
 

PROTEIN VIEW

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PAPPA-001
 
PAPPA-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PAPPA-001 ENSP00000330658
ENST00000328252
Q13219
Show all »
Show » Show » 1627 181 Yes 0
PAPPA-201 ENSP00000441461
ENST00000534838
F5GZ19
Show all »
Show » Show » 665 73.5 No 0