CHEK2 - Gene info - The Human Protein Atlas

CHEK2

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CHEK2 (HGNC Symbol)
Synonyms	bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53
Description	Checkpoint kinase 2 (HGNC Symbol)
Entrez gene summary	In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	22
Cytoband	q12.1
Chromosome location (bp)	29083731 - 29138410
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000183765 (version 75.37)
Entrez gene	11200
UniProt	O96017 (UniProt - Evidence at protein level)
neXtProt	NX_O96017
Antibodypedia	CHEK2 antibodies

PROTEIN VIEW

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CHEK2-001		CHEK2-002		CHEK2-003		CHEK2-004		CHEK2-005		CHEK2-006		CHEK2-008		CHEK2-009		CHEK2-010		CHEK2-011		CHEK2-012		CHEK2-013		CHEK2-014		CHEK2-015		CHEK2-018		CHEK2-019		CHEK2-021		CHEK2-022		CHEK2-023		CHEK2-201		CHEK2-202		CHEK2-203		CHEK2-204		CHEK2-205

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CHEK2-001	ENSP00000402225 ENST00000416671	E7EPP1 Show all » « Hide E7EPP1 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	207	23.1	No	0
CHEK2-002	ENSP00000329178 ENST00000328354	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:22%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	543	60.9	No	1
CHEK2-003	ENSP00000372023 ENST00000382580	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:20%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016301 [kinase activity] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	586	65.4	No	1
CHEK2-004	ENSP00000403659 ENST00000433028	F8WCV2 Show all » « Hide F8WCV2 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	161	18.2	No	0
CHEK2-005	ENSP00000386087 ENST00000405598	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:22%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	543	60.9	No	1
CHEK2-006	ENSP00000385747 ENST00000404276	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:22%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	543	60.9	No	1
CHEK2-008	ENSP00000404567 ENST00000448511	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases COSMIC Frameshift Mutations COSMIC Germline Mutations Enzymes ENZYME proteins Kinases Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	165	18.7	No	0
CHEK2-009	ENSP00000412901 ENST00000417588	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 H7C0V7 [Target identity:28%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases COSMIC Frameshift Mutations COSMIC Germline Mutations Enzymes ENZYME proteins Kinases Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	203	22.6	No	0
CHEK2-010	ENSP00000397478 ENST00000447421	B7ZBF6 Show all » « Hide B7ZBF6 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	299	34	No	0
CHEK2-011	ENSP00000390244 ENST00000425190	B7ZBF2 Show all » « Hide B7ZBF2 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0010332 [response to gamma radiation] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0042770 [signal transduction in response to DNA damage]	121	13.7	No	0
CHEK2-012	ENSP00000381099 ENST00000398017	B7ZBF8 Show all » « Hide B7ZBF8 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	172	19.3	Yes	0
CHEK2-013	ENSP00000408065 ENST00000439200	B7ZBF7 Show all » « Hide B7ZBF7 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	295	32.5	No	0
CHEK2-014	ENSP00000387451 ENST00000454252	H7BZ30 Show all » « Hide H7BZ30 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		45	4.8	No	0
CHEK2-015	ENSP00000396903 ENST00000439346	H7C0V7 Show all » « Hide H7C0V7 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	57	6.4	No	0
CHEK2-018	ENSP00000416721 ENST00000434810		Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	276	31.1	No	0
CHEK2-019	ENSP00000394430 ENST00000456369		Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	144	16.2	No	0
CHEK2-021	ENSP00000384919 ENST00000403642	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	452	50.2	No	1
CHEK2-022	ENSP00000384835 ENST00000402731	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	514	57.5	No	1
CHEK2-023	ENSP00000404400 ENST00000433728	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases COSMIC Frameshift Mutations COSMIC Germline Mutations Enzymes ENZYME proteins Kinases Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	289	32.1	No	0
CHEK2-201	ENSP00000329012 ENST00000348295	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	514	57.5	No	1
CHEK2-202	ENSP00000372006 ENST00000382565	C9JFD7 Show all » « Hide C9JFD7 [Target identity:100%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide COSMIC Frameshift Mutations COSMIC Germline Mutations Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		163	17.4	No	0
CHEK2-203	ENSP00000372007 ENST00000382566	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases COSMIC Frameshift Mutations COSMIC Germline Mutations Enzymes ENZYME proteins Kinases Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	289	32.1	No	0
CHEK2-204	ENSP00000372021 ENST00000382578	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:26%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	452	50.2	No	1
CHEK2-205	ENSP00000442458 ENST00000544772	O96017 Show all » « Hide O96017 [Direct mapping] Serine/threonine-protein kinase Chk2 B7ZBF2 [Target identity:37%; Query identity:100%] Serine/threonine-protein kinase Chk2	Show » « Hide Transferases CAMK Ser/Thr protein kinases Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins 1TM proteins predicted by MDM COSMIC Germline Mutations COSMIC Frameshift Mutations Enzymes ENZYME proteins Kinases Predicted membrane proteins Prediction method-based # TM segments-based Plasma proteins Cancer-related genes Candidate cancer biomarkers Mutational cancer driver genes COSMIC somatic mutations in cancer genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000077 [DNA damage checkpoint] GO:0000086 [G2/M transition of mitotic cell cycle] GO:0000781 [chromosome, telomeric region] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0006302 [double-strand break repair] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0006974 [response to DNA damage stimulus] GO:0006975 [DNA damage induced protein phosphorylation] GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage] GO:0010332 [response to gamma radiation] GO:0016605 [PML body] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019901 [protein kinase binding] GO:0031625 [ubiquitin protein ligase binding] GO:0042176 [regulation of protein catabolic process] GO:0042770 [signal transduction in response to DNA damage] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0044257 [cellular protein catabolic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0046872 [metal ion binding] GO:0050821 [protein stabilization] GO:0072428 [signal transduction involved in intra-S DNA damage checkpoint] GO:0090307 [spindle assembly involved in mitosis] GO:0090399 [replicative senescence]	322	36.2	No	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.