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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
ACTG1 (HGNC Symbol) |
Synonyms |
ACTG, DFNA20, DFNA26 |
Description |
Actin, gamma 1 (HGNC Symbol) |
Entrez gene summary |
Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, encoded by this gene, is a cytoplasmic actin found in non-muscle cells. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011] |
Chromosome |
17 |
Cytoband |
q25.3 |
Chromosome location (bp) |
79476997 - 79490873 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000184009 (version 75.37) |
Entrez gene |
71 |
UniProt |
P63261 (UniProt - Evidence at protein level) |
neXtProt |
NX_P63261 |
Antibodypedia |
ACTG1 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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ACTG1-001 |
ENSP00000331514
ENST00000331925
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P63261 Show all »
« Hide
P63261 [Direct mapping]Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed B4E3A4 [Target identity:94%; Query identity:100%]cDNA FLJ57283, highly similar to Actin, cytoplasmic 2 Q6PJ43 [Target identity:70%; Query identity:100%]ACTG1 protein B3KWQ3 [Target identity:67%; Query identity:100%]cDNA FLJ43573 fis, clone RECTM2001691, highly similar to Actin, cytoplasmic 2 I3L1U9 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96FU6 [Target identity:44%; Query identity:100%]ACTG1 protein I3L3R2 [Target identity:43%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96DE1 [Target identity:42%; Query identity:100%]Putative uncharacterized protein A5GZ75 [Target identity:40%; Query identity:100%]Beta-actin A4UCT3 [Target identity:35%; Query identity:100%]Beta-actin A1E282 [Target identity:32%; Query identity:100%]Beta-actin Q562Z7 [Target identity:27%; Query identity:100%]Actin-like protein Q9UE89 [Target identity:18%; Query identity:100%]Beta-actin
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Plasma proteins Cytoskeleton related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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375 |
41.8 |
No |
0 |
ACTG1-002 |
ENSP00000459124
ENST00000575087
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P63261 Show all »
« Hide
P63261 [Direct mapping]Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed B4E3A4 [Target identity:94%; Query identity:100%]cDNA FLJ57283, highly similar to Actin, cytoplasmic 2 Q6PJ43 [Target identity:70%; Query identity:100%]ACTG1 protein B3KWQ3 [Target identity:67%; Query identity:100%]cDNA FLJ43573 fis, clone RECTM2001691, highly similar to Actin, cytoplasmic 2 I3L1U9 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96FU6 [Target identity:44%; Query identity:100%]ACTG1 protein I3L3R2 [Target identity:43%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96DE1 [Target identity:42%; Query identity:100%]Putative uncharacterized protein A5GZ75 [Target identity:40%; Query identity:100%]Beta-actin A4UCT3 [Target identity:35%; Query identity:100%]Beta-actin A1E282 [Target identity:32%; Query identity:100%]Beta-actin Q562Z7 [Target identity:27%; Query identity:100%]Actin-like protein Q9UE89 [Target identity:18%; Query identity:100%]Beta-actin
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Plasma proteins Cytoskeleton related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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375 |
41.8 |
No |
0 |
ACTG1-003 |
ENSP00000458435
ENST00000573283
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P63261 Show all »
« Hide
P63261 [Direct mapping]Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed B4E3A4 [Target identity:94%; Query identity:100%]cDNA FLJ57283, highly similar to Actin, cytoplasmic 2 Q6PJ43 [Target identity:70%; Query identity:100%]ACTG1 protein B3KWQ3 [Target identity:67%; Query identity:100%]cDNA FLJ43573 fis, clone RECTM2001691, highly similar to Actin, cytoplasmic 2 I3L1U9 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96FU6 [Target identity:44%; Query identity:100%]ACTG1 protein I3L3R2 [Target identity:43%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96DE1 [Target identity:42%; Query identity:100%]Putative uncharacterized protein A5GZ75 [Target identity:40%; Query identity:100%]Beta-actin A4UCT3 [Target identity:35%; Query identity:100%]Beta-actin A1E282 [Target identity:32%; Query identity:100%]Beta-actin Q562Z7 [Target identity:27%; Query identity:100%]Actin-like protein Q9UE89 [Target identity:18%; Query identity:100%]Beta-actin
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Show »
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Plasma proteins Cytoskeleton related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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375 |
41.8 |
No |
0 |
ACTG1-006 |
ENSP00000461672
ENST00000576544
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P63261 Show all »
« Hide
P63261 [Direct mapping]Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed B4E3A4 [Target identity:94%; Query identity:100%]cDNA FLJ57283, highly similar to Actin, cytoplasmic 2 Q6PJ43 [Target identity:70%; Query identity:100%]ACTG1 protein B3KWQ3 [Target identity:67%; Query identity:100%]cDNA FLJ43573 fis, clone RECTM2001691, highly similar to Actin, cytoplasmic 2 I3L1U9 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96FU6 [Target identity:44%; Query identity:100%]ACTG1 protein I3L3R2 [Target identity:43%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96DE1 [Target identity:42%; Query identity:100%]Putative uncharacterized protein A5GZ75 [Target identity:40%; Query identity:100%]Beta-actin A4UCT3 [Target identity:35%; Query identity:100%]Beta-actin A1E282 [Target identity:32%; Query identity:100%]Beta-actin Q562Z7 [Target identity:27%; Query identity:100%]Actin-like protein Q9UE89 [Target identity:18%; Query identity:100%]Beta-actin
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Show »
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Plasma proteins Cytoskeleton related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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375 |
41.8 |
No |
0 |
ACTG1-010 |
ENSP00000459119
ENST00000575659
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I3L1U9 Show all »
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I3L1U9 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3R2 [Target identity:76%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed A1E282 [Target identity:56%; Query identity:100%]Beta-actin Q562Z7 [Target identity:48%; Query identity:100%]Actin-like protein
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Show »
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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214 |
23.8 |
No |
0 |
ACTG1-011 |
ENSP00000460464
ENST00000575994
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I3L1U9 Show all »
« Hide
I3L1U9 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3R2 [Target identity:76%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed A1E282 [Target identity:56%; Query identity:100%]Beta-actin Q562Z7 [Target identity:48%; Query identity:100%]Actin-like protein
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Show »
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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214 |
23.8 |
No |
0 |
ACTG1-012 |
ENSP00000458162
ENST00000575842
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P63261 Show all »
« Hide
P63261 [Direct mapping]Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed B4E3A4 [Target identity:94%; Query identity:100%]cDNA FLJ57283, highly similar to Actin, cytoplasmic 2 Q6PJ43 [Target identity:70%; Query identity:100%]ACTG1 protein B3KWQ3 [Target identity:67%; Query identity:100%]cDNA FLJ43573 fis, clone RECTM2001691, highly similar to Actin, cytoplasmic 2 I3L1U9 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed I3L3I0 [Target identity:57%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96FU6 [Target identity:44%; Query identity:100%]ACTG1 protein I3L3R2 [Target identity:43%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q96DE1 [Target identity:42%; Query identity:100%]Putative uncharacterized protein A5GZ75 [Target identity:40%; Query identity:100%]Beta-actin A4UCT3 [Target identity:35%; Query identity:100%]Beta-actin A1E282 [Target identity:32%; Query identity:100%]Beta-actin Q562Z7 [Target identity:27%; Query identity:100%]Actin-like protein Q9UE89 [Target identity:18%; Query identity:100%]Beta-actin
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Show »
« Hide
Plasma proteins Cytoskeleton related proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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375 |
41.8 |
No |
0 |
ACTG1-013 |
ENSP00000460660
ENST00000571721
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I3L3R2 Show all »
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I3L3R2 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed A1E282 [Target identity:73%; Query identity:100%]Beta-actin
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Show »
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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164 |
18 |
No |
0 |
ACTG1-014 |
ENSP00000466346
ENST00000570382
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K7EM38 Show all »
« Hide
K7EM38 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed
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Show »
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Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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133 |
14.5 |
No |
0 |
ACTG1-015 |
ENSP00000462823
ENST00000572105
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J3KT65 Show all »
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J3KT65 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed
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Show »
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Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
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198 |
21.8 |
No |
0 |
ACTG1-017 |
ENSP00000461407
ENST00000571691
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I3L4N8 Show all »
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I3L4N8 [Target identity:100%; Query identity:100%]Actin, cytoplasmic 2, N-terminally processed Q562Z7 [Target identity:42%; Query identity:100%]Actin-like protein
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Show »
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Cytoskeleton related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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Show »
« Hide
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242 |
26.9 |
No |
0 |
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