GP1BA

GENE INFORMATION

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Gene name

GP1BA (HGNC Symbol)

Synonyms

CD42b, GP1B

Description

Glycoprotein Ib (platelet), alpha polypeptide (HGNC Symbol)

Entrez gene summary

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]

Chromosome

17

Cytoband

p13.2

Chromosome location (bp)

4835592 - 4838325

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185245 (version 75.37)

Entrez gene

2811

UniProt

P07359 (UniProt - Evidence at protein level)

neXtProt

NX_P07359

Antibodypedia

GP1BA antibodies
 

PROTEIN VIEW

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GP1BA-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GP1BA-001 ENSP00000329380
ENST00000329125
P07359
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Show » Show » 652 71.5 Yes 1