ROR1

GENE INFORMATION

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Gene name

ROR1 (HGNC Symbol)

Synonyms

NTRKR1

Description

Receptor tyrosine kinase-like orphan receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

Chromosome

1

Cytoband

p31.3

Chromosome location (bp)

64239693 - 64647181

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185483 (version 75.37)

Entrez gene

4919

UniProt

Q01973 (UniProt - Evidence at protein level)

neXtProt

NX_Q01973

Antibodypedia

ROR1 antibodies
 

PROTEIN VIEW

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ROR1-001
 
ROR1-002
 
ROR1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ROR1-001 ENSP00000360120
ENST00000371079
Q01973
Show all »
Show » Show » 937 104.3 Yes 1
ROR1-002 ENSP00000360121
ENST00000371080
Q01973
Show all »
Show » Show » 393 43.8 Yes 0
ROR1-201 ENSP00000441637
ENST00000545203
Q01973
Show all »
Show » Show » 388 42.8 No 0