HYAL3

GENE INFORMATION

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Gene name

HYAL3 (HGNC Symbol)

Synonyms

LUCA-3, LUCA14, Minna14

Description

Hyaluronoglucosaminidase 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Chromosome

3

Cytoband

p21.31

Chromosome location (bp)

50330262 - 50336899

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186792 (version 75.37)

Entrez gene

8372

UniProt

O43820 (UniProt - Evidence at transcript level)

neXtProt

NX_O43820

Antibodypedia

HYAL3 antibodies
 

PROTEIN VIEW

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HYAL3-001
 
HYAL3-002
 
HYAL3-003
 
HYAL3-004
 
HYAL3-005
 
HYAL3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HYAL3-001 ENSP00000337425
ENST00000336307
O43820
Show all »
Show » Show » 417 46.5 Yes 0
HYAL3-002 ENSP00000351946
ENST00000359051
O43820
Show all »
Show » Show » 387 43.6 Yes 0
HYAL3-003 ENSP00000401092
ENST00000415204
O43820
Show all »
Show » Show » 168 18.8 No 0
HYAL3-004 ENSP00000391663
ENST00000435141
C9JB51
Show all »
Show » Show » 160 17.7 Yes 0
HYAL3-005 ENSP00000424633
ENST00000513170
O43820
Show all »
Show » Show » 138 15.9 No 0
HYAL3-201 ENSP00000391922
ENST00000450982
O43820
Show all »
Show » Show » 387 43.6 Yes 0