TNFRSF18

GENE INFORMATION

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Gene name

TNFRSF18 (HGNC Symbol)

Synonyms

AITR, CD357, GITR

Description

Tumor necrosis factor receptor superfamily, member 18 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Feb 2011]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

1138888 - 1142071

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000186891 (version 75.37)

Entrez gene

8784

UniProt

Q9Y5U5 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y5U5

Antibodypedia

TNFRSF18 antibodies
 

PROTEIN VIEW

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TNFRSF18-001
 
TNFRSF18-002
 
TNFRSF18-003
 
TNFRSF18-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF18-001 ENSP00000368570
ENST00000379268
Q9Y5U5
Show all »
Show » Show » 241 26 Yes 1
TNFRSF18-002 ENSP00000368567
ENST00000379265
Q9Y5U5
Show all »
Show » Show » 234 25.1 Yes 1
TNFRSF18-003 ENSP00000328207
ENST00000328596
Q9Y5U5
Show all »
Show » Show » 255 26.8 Yes 0
TNFRSF18-004 ENSP00000462735
ENST00000486728
J3KT02
Show all »
Show » Show » 169 18.5 No 1