DAZ3

GENE INFORMATION

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Gene name

DAZ3

Synonyms

Description

Deleted in azoospermia 3 (HGNC Symbol)

Entrez gene summary

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. [provided by RefSeq, Jul 2008]

Chromosome

Y

Cytoband

q11.23

Chromosome location (bp)

26909216 - 26959626

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187191 (version 75.37)

Entrez gene

57054

UniProt

Q9NR90 (UniProt - Evidence at protein level)

neXtProt

NX_Q9NR90

Antibodypedia

DAZ3 antibodies
 

PROTEIN VIEW

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DAZ3-001
 
DAZ3-201
 
DAZ3-202
 
DAZ3-203
 
DAZ3-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAZ3-001 ENSP00000371802
ENST00000382365
Q9NR90
Show all »
Show » Show » 438 49.5 No 0
DAZ3-201 ENSP00000307537
ENST00000306737
E7EUF4
Show all »
Show » 337 37.6 No 0
DAZ3-202 ENSP00000324965
ENST00000315357
E7ETR3
Show all »
Show » 366 41.3 No 0
DAZ3-203 ENSP00000383073
ENST00000400212
E7EU98
Show all »
Show » 361 40.3 No 0
DAZ3-204 ENSP00000401049
ENST00000446723
E7ERQ6
Show all »
Show » 390 44.1 No 0