LIN28B

GENE INFORMATION

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Gene name

LIN28B (HGNC Symbol)

Synonyms

CSDD2, FLJ16517

Description

Lin-28 homolog B (C. elegans) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

Chromosome

6

Cytoband

q16.3

Chromosome location (bp)

105404923 - 105531207

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187772 (version 75.37)

Entrez gene

389421

UniProt

Q6ZN17 (UniProt - Evidence at protein level)

neXtProt

NX_Q6ZN17

Antibodypedia

LIN28B antibodies
 

PROTEIN VIEW

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LIN28B-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LIN28B-001 ENSP00000344401
ENST00000345080
Q6ZN17
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