DMBT1

GENE INFORMATION

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Gene name

DMBT1 (HGNC Symbol)

Synonyms

GP340, muclin

Description

Deleted in malignant brain tumors 1 (HGNC Symbol)

Entrez gene summary

Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor suppressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Nov 2014]

Chromosome

10

Cytoband

q26.13

Chromosome location (bp)

124320181 - 124403252

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000187908 (version 75.37)

Entrez gene

1755

UniProt

Q9UGM3 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UGM3

Antibodypedia

DMBT1 antibodies
 

PROTEIN VIEW

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DMBT1-001
 
DMBT1-002
 
DMBT1-003
 
DMBT1-201
 
DMBT1-202
 
DMBT1-203
 
DMBT1-204
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DMBT1-001 ENSP00000342210
ENST00000338354
Q9UGM3
Show all »
Show » Show » 2413 260.7 Yes 0
DMBT1-002 ENSP00000343175
ENST00000344338
Q9UGM3
Show all »
Show » Show » 2403 259.7 Yes 0
DMBT1-003 ENSP00000327747
ENST00000330163
Q9UGM3
Show all »
Show » Show » 1785 194 Yes 0
DMBT1-201 ENSP00000352593
ENST00000359586
F8WEF7
Show all »
Show » Show » 1133 124.5 Yes 0
DMBT1-202 ENSP00000357905
ENST00000368909
Q9UGM3
Show all »
Show » Show » 2413 260.7 Yes 0
DMBT1-203 ENSP00000357951
ENST00000368955
Q9UGM3
Show all »
Show » Show » 2403 259.7 Yes 0
DMBT1-204 ENSP00000357952
ENST00000368956
Q9UGM3
Show all »
Show » Show » 1785 194 Yes 0