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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version. The Entrez gene identifier for the gene is also given. If any of the protein products of the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the neXtProt databases for these proteins are displayed.
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Gene name |
SPN (HGNC Symbol) |
Synonyms |
CD43, GPL115, LSN |
Description |
Sialophorin (HGNC Symbol) |
Entrez gene summary |
The protein encoded by this gene is a major sialoglycoprotein found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It may be part of a physiologic ligand-receptor complex involved in T-cell activation. During T-cell activation, this protein is actively removed from the T-cell-APC (antigen-presenting cell) contact site, suggesting a negative regulatory role in adaptive immune response. [provided by RefSeq, Sep 2011] |
Chromosome |
16 |
Cytoband |
p11.2 |
Chromosome location (bp) |
29674300 - 29682187 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000197471 (version 75.37) |
Entrez gene |
6693 |
UniProt |
P16150 (UniProt - Evidence at protein level) |
neXtProt |
NX_P16150 |
Antibodypedia |
SPN antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between alternative processed transcripts from the same gene are also displayed ( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website for that protein, and the ENST identifier links to the Ensembl website for that transcript. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues) (according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0 and Phobius and predicted transmembrane region(s) (according to MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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SPN-001 |
ENSP00000378787
ENST00000395389
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P16150 Show all »
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P16150 [Direct mapping]Leukosialin A8K9B1 [Target identity:100%; Query identity:100%]Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a; cDNA FLJ77999, highly similar to Homo sapiens sialophorin (gpL115, leukosialin, CD43), mRNA; cDNA, FLJ94351, Homo sapiens sialophorin (gpL115, leukosialin, CD43) (SPN), mRNA C9JUK7 [Target identity:88%; Query identity:100%]Leukosialin
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Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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400 |
40.3 |
Yes |
1 |
SPN-002 |
ENSP00000412907
ENST00000436527
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C9JUK7 Show all »
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C9JUK7 [Target identity:100%; Query identity:100%]Leukosialin
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Show »
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Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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355 |
36 |
Yes |
1 |
SPN-003 |
ENSP00000455266
ENST00000563039
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P16150 Show all »
« Hide
P16150 [Direct mapping]Leukosialin A8K9B1 [Target identity:100%; Query identity:100%]Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a; cDNA FLJ77999, highly similar to Homo sapiens sialophorin (gpL115, leukosialin, CD43), mRNA; cDNA, FLJ94351, Homo sapiens sialophorin (gpL115, leukosialin, CD43) (SPN), mRNA C9JUK7 [Target identity:88%; Query identity:100%]Leukosialin
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Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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400 |
40.3 |
Yes |
1 |
SPN-201 |
ENSP00000353238
ENST00000360121
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P16150 Show all »
« Hide
P16150 [Direct mapping]Leukosialin A8K9B1 [Target identity:100%; Query identity:100%]Sialophorin (GpL115, leukosialin, CD43), isoform CRA_a; cDNA FLJ77999, highly similar to Homo sapiens sialophorin (gpL115, leukosialin, CD43), mRNA; cDNA, FLJ94351, Homo sapiens sialophorin (gpL115, leukosialin, CD43) (SPN), mRNA C9JUK7 [Target identity:88%; Query identity:100%]Leukosialin
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Show »
« Hide
Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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400 |
40.3 |
Yes |
1 |
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