SLC22A12

GENE INFORMATION

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Gene name

SLC22A12 (HGNC Symbol)

Synonyms

OAT4L, RST, URAT1

Description

Solute carrier family 22 (organic anion/urate transporter), member 12 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

64358113 - 64369820

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197891 (version 75.37)

Entrez gene

116085

UniProt

Q96S37 (UniProt - Evidence at protein level)

neXtProt

NX_Q96S37

Antibodypedia

SLC22A12 antibodies
 

PROTEIN VIEW

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SLC22A12-001
 
SLC22A12-002
 
SLC22A12-004
 
SLC22A12-005
 
SLC22A12-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC22A12-001 ENSP00000366797
ENST00000377574
Q96S37
Show all »
Show » Show » 553 59.6 No >9
SLC22A12-002 ENSP00000366790
ENST00000377567
Q96S37
Show all »
Show » Show » 445 47.6 No 8
SLC22A12-004 ENSP00000438437
ENST00000473690
G3XAN7
Show all »
Show » Show » 332 35.6 No 8
SLC22A12-005 ENSP00000336836
ENST00000336464
B5ME56
Show all »
Show » Show » 519 56.1 No >9
SLC22A12-201 ENSP00000366795
ENST00000377572
Q96S37
Show all »
Show » Show » 445 47.6 No 8