TXNRD1 - Gene info - The Human Protein Atlas

TXNRD1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	TXNRD1 (HGNC Symbol)
Synonyms	GRIM-12, Trxr1, TXNR
Description	Thioredoxin reductase 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q23.3
Chromosome location (bp)	104609557 - 104744061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198431 (version 75.37)
Entrez gene	7296
UniProt	Q16881 (UniProt - Evidence at protein level)
neXtProt	NX_Q16881
Antibodypedia	TXNRD1 antibodies

PROTEIN VIEW

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TXNRD1-001		TXNRD1-002		TXNRD1-003		TXNRD1-004		TXNRD1-005		TXNRD1-006		TXNRD1-007		TXNRD1-009		TXNRD1-012		TXNRD1-013		TXNRD1-014		TXNRD1-015		TXNRD1-016		TXNRD1-017		TXNRD1-020		TXNRD1-021		TXNRD1-201		TXNRD1-202		TXNRD1-203		TXNRD1-204		TXNRD1-205		TXNRD1-206		TXNRD1-207		TXNRD1-208

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
TXNRD1-001	ENSP00000434516 ENST00000525566	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic B7Z904 [Target identity:99%; Query identity:100%] Thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; cDNA FLJ56205, highly similar to Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:76%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:70%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:26%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:11%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:10%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:6%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0007369 [gastrulation] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	649	70.9	No
TXNRD1-002	ENSP00000435929 ENST00000526691	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:90%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:83%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:31%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:13%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:7%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	551	60.4	No
TXNRD1-003	ENSP00000421934 ENST00000503506	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:99%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:91%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:35%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:10%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	499	54.8	No
TXNRD1-004	ENSP00000434919 ENST00000529546	F5H780 Show all » « Hide F5H780 [Target identity:99%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	461	50.9	No
TXNRD1-005	ENSP00000433887 ENST00000526580	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:69%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:67%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:50%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0008033 [tRNA processing] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	104	11.3	No
TXNRD1-006	ENSP00000433425 ENST00000524698	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:99%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:91%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:35%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:10%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	499	54.8	No
TXNRD1-007	ENSP00000433935 ENST00000527688	E9PIR7 Show all » « Hide E9PIR7 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:36%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:10%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	482	53.2	No
TXNRD1-009	ENSP00000432812 ENST00000526950	B2R5P6 Show all » « Hide B2R5P6 [Target identity:87%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:80%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:30%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PJU2 [Target identity:16%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:7%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	568	62.1	No
TXNRD1-012	ENSP00000431294 ENST00000526266	E9PLT3 Show all » « Hide E9PLT3 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:75%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008033 [tRNA processing] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	70	7.3	No
TXNRD1-013	ENSP00000433507 ENST00000531689	E9PKI4 Show all » « Hide E9PKI4 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:97%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:73%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008033 [tRNA processing] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	72	7.6	No
TXNRD1-014	ENSP00000433599 ENST00000527335	E9PKD3 Show all » « Hide E9PKD3 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:41%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:40%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:30%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008033 [tRNA processing] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	175	19.4	No
TXNRD1-015	ENSP00000436229 ENST00000529784	E9PQI3 Show all » « Hide E9PQI3 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008033 [tRNA processing] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	53	5.6	No
TXNRD1-016	ENSP00000431925 ENST00000531691	E9PIZ5 Show all » « Hide E9PIZ5 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:51%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:50%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:38%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008033 [tRNA processing] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	139	15.1	No
TXNRD1-017	ENSP00000435123 ENST00000526390	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic E2QRB9 [Target identity:99%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:91%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:84%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:32%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:13%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	543	59.8	No
TXNRD1-020	ENSP00000433732 ENST00000528079	E9PJU2 Show all » « Hide E9PJU2 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Phobius predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004791 [thioredoxin-disulfide reductase activity] GO:0045454 [cell redox homeostasis] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding]	96	10.1	No
TXNRD1-021	ENSP00000432273 ENST00000529751	E9PRI8 Show all » « Hide E9PRI8 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	44	4.8	No
TXNRD1-201	ENSP00000347020 ENST00000354940	B2R5P6 Show all » « Hide B2R5P6 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:92%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:35%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:14%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:10%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	497	54.5	No
TXNRD1-202	ENSP00000367310 ENST00000378070	E7ESI6 Show all » « Hide E7ESI6 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PIR7 [Target identity:82%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:30%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:7%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	581	64	No
TXNRD1-203	ENSP00000373506 ENST00000388854	Q16881 Show all » « Hide Q16881 [Direct mapping] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:90%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:83%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:31%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:13%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide Oxidoreductases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0007165 [signal transduction] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0015949 [nucleobase-containing small molecule interconversion] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	549	60.2	No
TXNRD1-204	ENSP00000380844 ENST00000397736	E2QRB9 Show all » « Hide E2QRB9 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:91%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:84%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:32%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:13%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	541	59.6	No
TXNRD1-205	ENSP00000393328 ENST00000427956	E7EW10 Show all » « Hide E7EW10 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:81%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:75%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:28%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PJU2 [Target identity:15%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:11%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:11%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:7%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	612	67.1	No
TXNRD1-206	ENSP00000412045 ENST00000429002	B7Z904 Show all » « Hide B7Z904 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1; Thioredoxin reductase 1, cytoplasmic; cDNA FLJ56205, highly similar to Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:76%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:70%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:27%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:11%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:10%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:6%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	647	70.7	No
TXNRD1-207	ENSP00000442709 ENST00000540716	F5H780 Show all » « Hide F5H780 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	459	50.7	No
TXNRD1-208	ENSP00000440978 ENST00000542918	B7Z2S5 Show all » « Hide B7Z2S5 [Target identity:100%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA FLJ56075, highly similar to Thioredoxin reductase 1, cytoplasmic B2R5P6 [Target identity:90%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic; cDNA, FLJ92557, highly similar to Homo sapiens thioredoxin reductase 1 (TXNRD1), mRNA F5H780 [Target identity:83%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKD3 [Target identity:31%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PKI4 [Target identity:13%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PLT3 [Target identity:12%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PQI3 [Target identity:9%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic E9PRI8 [Target identity:8%; Query identity:100%] Thioredoxin reductase 1, cytoplasmic	Show » « Hide SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001707 [mesoderm formation] GO:0001890 [placenta development] GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006749 [glutathione metabolic process] GO:0008283 [cell proliferation] GO:0009055 [electron carrier activity] GO:0010269 [response to selenium ion] GO:0010942 [positive regulation of cell death] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016174 [NAD(P)H oxidase activity] GO:0016259 [selenocysteine metabolic process] GO:0016491 [oxidoreductase activity] GO:0016668 [oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor] GO:0033797 [selenate reductase activity] GO:0042191 [methylmercury metabolic process] GO:0042493 [response to drug] GO:0042537 [benzene-containing compound metabolic process] GO:0042744 [hydrogen peroxide catabolic process] GO:0042803 [protein homodimerization activity] GO:0043025 [neuronal cell body] GO:0045340 [mercury ion binding] GO:0045454 [cell redox homeostasis] GO:0048678 [response to axon injury] GO:0050660 [flavin adenine dinucleotide binding] GO:0050661 [NADP binding] GO:0051262 [protein tetramerization] GO:0055114 [oxidation-reduction process] GO:0070276 [halogen metabolic process] GO:0070995 [NADPH oxidation] GO:0071280 [cellular response to copper ion] GO:0071455 [cellular response to hyperoxia]	547	60	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.