GRM3

GENE INFORMATION

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Gene name

GRM3 (HGNC Symbol)

Synonyms

GPRC1C, mGlu3, MGLUR3

Description

Glutamate receptor, metabotropic 3 (HGNC Symbol)

Entrez gene summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

q21.11

Chromosome location (bp)

86273230 - 86494200

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198822 (version 75.37)

Entrez gene

2913

UniProt

Q14832 (UniProt - Evidence at protein level)

neXtProt

NX_Q14832

Antibodypedia

GRM3 antibodies
 

PROTEIN VIEW

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GRM3-001
 
GRM3-002
 
GRM3-003
 
GRM3-004
 
GRM3-005
 
GRM3-201
 
GRM3-202
 
GRM3-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRM3-001 ENSP00000355316
ENST00000361669
Q14832
Show all »
Show » Show » 879 98.9 Yes 7
GRM3-002 ENSP00000390037
ENST00000421579
C9JIT1
Show all »
Show » Show » 87 9.9 Yes 0
GRM3-003 ENSP00000407490
ENST00000441140
C9JUH9
Show all »
Show » Show » 81 9.1 Yes 0
GRM3-004 ENSP00000405427
ENST00000454217
C9J2I2
Show all »
Show » Show » 171 19 No 0
GRM3-005 ENSP00000398767
ENST00000439827
Q14832
Show all »
Show » Show » 537 60.7 Yes 0
GRM3-201 ENSP00000378209
ENST00000394720
Q14832
Show all »
Show » Show » 535 60.5 Yes 0
GRM3-202 ENSP00000441407
ENST00000536043
F5GYZ2
Show all »
Show » Show » 751 84.4 No 7
GRM3-203 ENSP00000444064
ENST00000546348
B7Z204
Show all »
Show » Show » 471 52.3 No 7