SSX4

GENE INFORMATION

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Gene name

SSX4 (HGNC Symbol)

Synonyms

CT5.4

Description

Synovial sarcoma, X breakpoint 4 (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48242863 - 48252785

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000204645 (version 75.37)

Entrez gene

6759

UniProt

O60224 (UniProt - Evidence at transcript level)

neXtProt

NX_O60224

Antibodypedia

SSX4 antibodies
 

PROTEIN VIEW

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SSX4-001
 
SSX4-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SSX4-001 ENSP00000366083
ENST00000376886
O60224
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Show » Show » 188 21.9 No 0
SSX4-002 ENSP00000364667
ENST00000375517
A8MYD4
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Show » Show » 153 17.9 No 0