KLRC3

GENE INFORMATION

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Gene name

KLRC3 (HGNC Symbol)

Synonyms

NKG2-E

Description

Killer cell lectin-like receptor subfamily C, member 3 (HGNC Symbol)

Entrez gene summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

p13.2

Chromosome location (bp)

10564911 - 10573194

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205810 (version 75.37)

Entrez gene

3823

UniProt

Q07444 (UniProt - Evidence at transcript level)

neXtProt

NX_Q07444

Antibodypedia

KLRC3 antibodies
 

PROTEIN VIEW

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KLRC3-002
 
KLRC3-003
 
KLRC3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KLRC3-002 ENSP00000379716
ENST00000396439
Q07444
Show all »
Show » Show » 240 27.1 No 1
KLRC3-003 ENSP00000371328
ENST00000381903
Q07444
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Show » Show » 257 29 No 1
KLRC3-201 ENSP00000371329
ENST00000381904
J3KPJ5
Show all »
Show » Show » 240 27.2 No 1