DAZ4

GENE INFORMATION

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Gene name

DAZ4

Synonyms

Description

Deleted in azoospermia 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]

Chromosome

Y

Cytoband

q11.23

Chromosome location (bp)

26980008 - 27053183

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205916 (version 75.37)

Entrez gene

57135

UniProt

Q86SG3 (UniProt - Evidence at protein level)

neXtProt

NX_Q86SG3

Antibodypedia

DAZ4 antibodies
 

PROTEIN VIEW

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DAZ4-001
 
DAZ4-003
 
DAZ4-201
 
DAZ4-202
 
DAZ4-203
 
DAZ4-204
 
DAZ4-205
 
DAZ4-206
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAZ4-001 ENSP00000371751
ENST00000382314
Q86SG3
Show all »
Show » Show » 390 44.1 No 0
DAZ4-003 ENSP00000371733
ENST00000382296
E7EU38
Show all »
Show » 413 46.7 No 0
DAZ4-201 ENSP00000371727
ENST00000382290
F6S8J2
Show all »
Show » 334 37.3 No 0
DAZ4-202 ENSP00000371869
ENST00000382432
E7ENA5
Show all »
Show » 382 42.8 No 0
DAZ4-203 ENSP00000383341
ENST00000400494
E7ENA5
Show all »
Show » 382 42.8 No 0
DAZ4-204 ENSP00000397895
ENST00000415508
E7EU39
Show all »
Show » 366 41.3 No 0
DAZ4-205 ENSP00000401363
ENST00000440066
Q86SG3
Show all »
Show » Show » 579 64.8 No 0
DAZ4-206 ENSP00000389300
ENST00000449750
Q86SG3
Show all »
Show » Show » 390 44.1 No 0