DAZ2

GENE INFORMATION

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Gene name

DAZ2 (HGNC Symbol)

Synonyms

MGC126442, pDP1678

Description

Deleted in azoospermia 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

Y

Cytoband

q11.223

Chromosome location (bp)

25365594 - 25437503

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000205944 (version 75.37)

Entrez gene

57055

UniProt

Q13117 (UniProt - Evidence at protein level)

neXtProt

NX_Q13117

Antibodypedia

DAZ2 antibodies
 

PROTEIN VIEW

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DAZ2-001
 
DAZ2-002
 
DAZ2-003
 
DAZ2-201
 
DAZ2-202
 
DAZ2-203
 
DAZ2-204
 
DAZ2-205
 
DAZ2-206
 
DAZ2-207
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DAZ2-001 ENSP00000371887
ENST00000382449
Q13117
Show all »
Show » Show » 534 60.4 No 0
DAZ2-002 ENSP00000371870
ENST00000382433
Q13117
Show all »
Show » Show » 558 63.1 No 0
DAZ2-003 ENSP00000371877
ENST00000382440
E9PBY2
Show all »
Show » 654 74.1 No 0
DAZ2-201 ENSP00000371731
ENST00000382294
E7EU39
Show all »
Show » 366 41.3 No 0
DAZ2-202 ENSP00000371743
ENST00000382306
Q13117
Show all »
Show » Show » 534 60.4 No 0
DAZ2-203 ENSP00000371861
ENST00000382424
Q13117
Show all »
Show » Show » 558 63.1 No 0
DAZ2-204 ENSP00000371868
ENST00000382431
I3L0B6
Show all »
Show » 486 55 No 0
DAZ2-205 ENSP00000371871
ENST00000382434
E7EN82
Show all »
Show » 361 40.4 No 0
DAZ2-206 ENSP00000383340
ENST00000400493
E7ENA6
Show all »
Show » 438 49.6 No 0
DAZ2-207 ENSP00000414113
ENST00000449947
F6S8J2
Show all »
Show » 390 44.1 No 0