CSH2

GENE INFORMATION

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Gene name

CSH2 (HGNC Symbol)

Synonyms

CS-2, CSB, hCS-B

Description

Chorionic somatomammotropin hormone 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]

Chromosome

17

Cytoband

q23.3

Chromosome location (bp)

61949372 - 61951126

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000213218 (version 75.37)

Entrez gene

1443

UniProt

P01243

neXtProt

NX_P01243

Antibodypedia

CSH2 antibodies
 

PROTEIN VIEW

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CSH2-001
 
CSH2-002
 
CSH2-004
 
CSH2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CSH2-001 ENSP00000376623
ENST00000392886
P01243
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Show » Show » 217 25 Yes 0
CSH2-002 ENSP00000453452
ENST00000560142
H0YM39
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Show » Show » 160 18.4 Yes 0
CSH2-004 ENSP00000338816
ENST00000336844
A6NIT4
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Show » Show » 167 18.8 Yes 0
CSH2-201 ENSP00000308396
ENST00000345366
B1A4H9
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Show » Show » 122 13.9 Yes 0