PSG3

GENE INFORMATION

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Gene name

PSG3

Synonyms

Description

Pregnancy specific beta-1-glycoprotein 3 (HGNC Symbol)

Entrez gene summary

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

Chromosome

19

Cytoband

q13.2

Chromosome location (bp)

43225790 - 43244721

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000221826 (version 75.37)

Entrez gene

5671

UniProt

Q16557 (UniProt - Evidence at transcript level)

neXtProt

NX_Q16557

Antibodypedia

PSG3 antibodies
 

PROTEIN VIEW

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PSG3-001
 
PSG3-003
 
PSG3-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PSG3-001 ENSP00000332215
ENST00000327495
Q16557
Show all »
Show » Show » 428 47.9 Yes 0
PSG3-003 ENSP00000469292
ENST00000594378
M0QXP2
Show all »
Show » 91 10.1 No 0
PSG3-005 ENSP00000468936
ENST00000595140
M0QX68
Show all »
Show » Show » 475 53.9 Yes 0