SLC26A6 - Gene info - The Human Protein Atlas

Gene name

SLC26A6 (HGNC Symbol)

Synonyms

DKFZp586E1422

Description

Solute carrier family 26 (anion exchanger), member 6 (HGNC Symbol)

Entrez gene summary

This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2013]

Chromosome

Cytoband

p21.31

Chromosome location (bp)

48663156 - 48672926

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000225697 (version 75.37)

Entrez gene

65010

UniProt

Q9BXS9 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC26A6-001

ENSP00000404684
ENST00000420764

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422

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   >9TM proteins predicted by MDM
   TMHMM predicted membrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005254 [chloride channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006811 [ion transport]
GO:0006821 [chloride transport]
GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0012506 [vesicle membrane]
GO:0015106 [bicarbonate transmembrane transporter activity]
GO:0015108 [chloride transmembrane transporter activity]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0015301 [anion:anion antiporter activity]
GO:0015499 [formate transmembrane transporter activity]
GO:0015562 [efflux transmembrane transporter activity]
GO:0015659 [formate uptake transmembrane transporter activity]
GO:0015660 [formate efflux transmembrane transporter activity]
GO:0015701 [bicarbonate transport]
GO:0015724 [formate transport]
GO:0015797 [mannitol transport]
GO:0016020 [membrane]
GO:0016021 [integral to membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019531 [oxalate transmembrane transporter activity]
GO:0019532 [oxalate transport]
GO:0030165 [PDZ domain binding]
GO:0030321 [transepithelial chloride transport]
GO:0030659 [cytoplasmic vesicle membrane]
GO:0031526 [brush border membrane]
GO:0031988 [membrane-bounded vesicle]
GO:0034707 [chloride channel complex]
GO:0038166 [angiotensin-mediated signaling pathway]
GO:0042045 [epithelial fluid transport]
GO:0046724 [oxalic acid secretion]
GO:0048240 [sperm capacitation]
GO:0050892 [intestinal absorption]
GO:0051453 [regulation of intracellular pH]
GO:0051454 [intracellular pH elevation]
GO:0055085 [transmembrane transport]
GO:0070528 [protein kinase C signaling cascade]
GO:0070633 [transepithelial transport]
GO:0071320 [cellular response to cAMP]
GO:0071332 [cellular response to fructose stimulus]
GO:0071346 [cellular response to interferon-gamma]
GO:0097225 [sperm midpiece]
GO:2001150 [positive regulation of dipeptide transmembrane transport]

758

82.8

SLC26A6-004

ENSP00000378920
ENST00000395550

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422

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759

SLC26A6-005

ENSP00000337648
ENST00000337000

G3XAC1
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G3XAC1 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6; Solute carrier family 26, member 6, isoform CRA_i
Q9Y3Y1 [Target identity:8%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   9TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral to membrane]

651

71.5

SLC26A6-006

ENSP00000373239
ENST00000383733

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q86YZ4 [Target identity:100%; Query identity:98%]
Solute carrier family 26, member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422

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740

80.8

SLC26A6-007

ENSP00000307089
ENST00000307364

F8W9I8
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F8W9I8 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6

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MEMSAT3 predicted membrane proteins
SPOCTOPUS predicted membrane proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

120

13.9

SLC26A6-009

ENSP00000401066
ENST00000455886

B4DMZ1
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B4DMZ1 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6; cDNA FLJ53405, highly similar to Solute carrier family 26 member 6
C9J6Y3 [Target identity:23%; Query identity:100%]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   >9TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral to membrane]

723

79.2

SLC26A6-015

ENSP00000389922
ENST00000421649

H7BZJ6
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H7BZJ6 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6

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GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral to membrane]

303

32.3

SLC26A6-016

ENSP00000404607
ENST00000444531

H7C291
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H7C291 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   4TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral to membrane]

217

SLC26A6-017

ENSP00000388721
ENST00000414944

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   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   1TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008272 [sulfate transport]
GO:0015116 [sulfate transmembrane transporter activity]
GO:0016021 [integral to membrane]

194

20.5

SLC26A6-020

ENSP00000387532
ENST00000431213

H7BZ36
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H7BZ36 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   3TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]

9.9

SLC26A6-021

ENSP00000401813
ENST00000431739

C9JKR6
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C9JKR6 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6

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   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   2TM proteins predicted by MDM
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]

180

20.2

SLC26A6-022

ENSP00000405872
ENST00000426599

C9J6Y3
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C9J6Y3 [Target identity:100%; Query identity:100%]
Solute carrier family 26 member 6

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GO:0008271 [secondary active sulfate transmembrane transporter activity]
GO:0008272 [sulfate transport]

169

18.8

SLC26A6-201

ENSP00000351597
ENST00000358747

Q9BXS9
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Q9BXS9 [Direct mapping]
Solute carrier family 26 member 6
Q9Y3Y1 [Target identity:7%; Query identity:100%]
Putative uncharacterized protein DKFZp586E1422

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738

80.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.