SPANXB2

GENE INFORMATION

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Gene name

SPANXB2

Synonyms

Description

SPANX family, member B2 (HGNC Symbol)

Entrez gene summary

Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-tail orientation with SPANX family member B1 and appears to be a duplication of that locus. The SPANXB genes are unique members of this gene family, since they contain an additional 18 nt in their coding region compared to the majority of family members. Although the protein encoded by this gene contains consensus nuclear localization signals, the major site for subcellular localization of expressed protein is in the cytoplasmic droplets of ejaculated spermatozoa. This protein provides a biochemical marker for studying the unique structures in spermatazoa, while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

q27.1

Chromosome location (bp)

140084756 - 140085871

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000227234 (version 75.37)

Entrez gene

100133171

UniProt

Q9NS25 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9NS25

Antibodypedia

SPANXB2 antibodies
 

PROTEIN VIEW

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SPANXB2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPANXB2-001 ENSP00000405202
ENST00000449283
Q9NS25
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