HSBP1

GENE INFORMATION

? »

Gene name

HSBP1

Synonyms

Description

Heat shock factor binding protein 1 (HGNC Symbol)

Entrez gene summary

The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

q23.3

Chromosome location (bp)

83841448 - 83853342

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000230989 (version 75.37)

Entrez gene

3281

UniProt

O75506 (UniProt - Evidence at protein level)

neXtProt

NX_O75506

Antibodypedia

HSBP1 antibodies
 

PROTEIN VIEW

? »
 
 
 
HSBP1-001
 
HSBP1-002
 
HSBP1-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HSBP1-001 ENSP00000392896
ENST00000433866
O75506
Show all »
Show » Show » 76 8.5 No 0
HSBP1-002 ENSP00000458007
ENST00000570259
O75506
Show all »
Show » Show » 76 8.5 No 0
HSBP1-003 ENSP00000456049
ENST00000567382
H3BR28
Show all »
Show » 66 6.7 No 0