HLA-B

GENE INFORMATION

? »

Gene name

HLA-B (HGNC Symbol)

Synonyms

AS

Description

Major histocompatibility complex, class I, B (HGNC Symbol)

Entrez gene summary

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.33

Chromosome location (bp)

31321649 - 31324965

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000234745 (version 75.37)

Entrez gene

3106

UniProt

P01889 (UniProt - Evidence at protein level), P30480 (UniProt - Evidence at protein level), P30486 (UniProt - Evidence at protein level), Q29836 (UniProt - Evidence at protein level), Q31610 (UniProt - Evidence at protein level), Q31612 (UniProt - Evidence at protein level)

neXtProt

NX_P01889, NX_P30480, NX_P30486, NX_Q29836, NX_Q31610, NX_Q31612

Antibodypedia

HLA-B antibodies
 

PROTEIN VIEW

? »
 
 
 
HLA-B-001
 
HLA-B-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-B-001 ENSP00000399168
ENST00000412585
P01889
Show all »
Show » Show » 362 40.5 Yes 1
HLA-B-003 ENSP00000405931
ENST00000434333
F6U0H7
Show all »
Show » Show » 246 27.8 No 0