UGT1A5

GENE INFORMATION

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Gene name

UGT1A5 (HGNC Symbol)

Synonyms

UGT1E

Description

UDP glucuronosyltransferase 1 family, polypeptide A5 (HGNC Symbol)

Entrez gene summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q37.1

Chromosome location (bp)

234621638 - 234681945

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000240224 (version 75.37)

Entrez gene

54579

UniProt

P35504 (UniProt - Evidence at transcript level)

neXtProt

NX_P35504

Antibodypedia

UGT1A5 antibodies
 

PROTEIN VIEW

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UGT1A5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UGT1A5-001 ENSP00000362513
ENST00000373414
P35504
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