CORT

GENE INFORMATION

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Gene name

CORT (HGNC Symbol)

Synonyms

MGC32686

Description

Cortistatin (HGNC Symbol)

Entrez gene summary

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

Chromosome

1

Cytoband

p36.22

Chromosome location (bp)

10509776 - 10511959

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000241563 (version 75.37)

Entrez gene

1325

UniProt

O00230 (UniProt - Evidence at transcript level)

neXtProt

NX_O00230

Antibodypedia

CORT antibodies
 

PROTEIN VIEW

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CORT-001
 
CORT-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CORT-001 ENSP00000366248
ENST00000377049
O00230
Show all »
Show » Show » 105 11.5 Yes 0
CORT-201 ENSP00000317110
ENST00000320498
O00230
Show all »
Show » Show » 155 17.2 No 0