PEG10

GENE INFORMATION

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Gene name

PEG10 (HGNC Symbol)

Synonyms

HB-1, KIAA1051, Mar2, Mart2, MEF3L, RGAG3

Description

Paternally expressed 10 (HGNC Symbol)

Entrez gene summary

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

Chromosome

7

Cytoband

q21.3

Chromosome location (bp)

94285637 - 94299007

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000242265 (version 75.37)

Entrez gene

23089

UniProt

Q86TG7 (UniProt - Evidence at protein level)

neXtProt

NX_Q86TG7

Antibodypedia

PEG10 antibodies
 

PROTEIN VIEW

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PEG10-001
 
PEG10-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PEG10-001 ENSP00000417587
ENST00000482108
Q86TG7
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Show » Show » 325 37 No 0
PEG10-002 ENSP00000418944
ENST00000488574
Q86TG7
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Show » Show » 325 37 No 0