PDCD6

GENE INFORMATION

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Gene name

PDCD6 (HGNC Symbol)

Synonyms

ALG-2, PEF1B

Description

Programmed cell death 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

271736 - 353971

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000249915 (version 75.37)

Entrez gene

10016

UniProt

O75340 (UniProt - Evidence at protein level)

neXtProt

NX_O75340

Antibodypedia

PDCD6 antibodies
 

PROTEIN VIEW

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PDCD6-001
 
PDCD6-002
 
PDCD6-006
 
PDCD6-008
 
PDCD6-011
 
PDCD6-012
 
PDCD6-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PDCD6-001 ENSP00000264933
ENST00000264933
O75340
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Show » Show » 191 21.9 No 0
PDCD6-002 ENSP00000424201
ENST00000505526
D6RA21
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Show » 39 4.1 No 0
PDCD6-006 ENSP00000422691
ENST00000509581
Q86W51
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Show » Show » 55 5.7 No 0
PDCD6-008 ENSP00000423815
ENST00000507528
O75340
Show all »
Show » Show » 189 21.7 No 0
PDCD6-011 ENSP00000422085
ENST00000505221
O75340
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Show » Show » 69 7.3 No 0
PDCD6-012 ENSP00000425370
ENST00000507473
H0Y9X3
Show all »
Show » Show » 104 12.2 No 0
PDCD6-014 ENSP00000426003
ENST00000506909
E7EPW6
Show all »
Show » Show » 73 7.8 No 0