PCDHGB2

GENE INFORMATION

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Gene name

PCDHGB2 (HGNC Symbol)

Synonyms

PCDH-GAMMA-B2

Description

Protocadherin gamma subfamily B, 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

140739703 - 140892546

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000253910 (version 75.37)

Entrez gene

56103

UniProt

Q9Y5G2 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9Y5G2

Antibodypedia

PCDHGB2 antibodies
 

PROTEIN VIEW

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PCDHGB2-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCDHGB2-001 ENSP00000429018
ENST00000522605
Q9Y5G2
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