PCDHGB4

GENE INFORMATION

? »

Gene name

PCDHGB4 (HGNC Symbol)

Synonyms

CDH20, FIB2, PCDH-GAMMA-B4

Description

Protocadherin gamma subfamily B, 4 (HGNC Symbol)

Entrez gene summary

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

140767452 - 140892546

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000253953 (version 75.37)

Entrez gene

8641

UniProt

Q9UN71 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UN71

Antibodypedia

PCDHGB4 antibodies
 

PROTEIN VIEW

? »
 
 
 
PCDHGB4-001
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCDHGB4-001 ENSP00000428288
ENST00000519479
Q9UN71
Show all »
Show » Show » 923 99.9 Yes 1