SPEN

GENE INFORMATION

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Gene name

SPEN (HGNC Symbol)

Synonyms

KIAA0929, MINT, RBM15C, SHARP

Description

Spen family transcriptional repressor (HGNC Symbol)

Entrez gene summary

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p36.13

Chromosome location (bp)

16174359 - 16266955

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000065526 (version 75.37)

Entrez gene

23013

UniProt

Q96T58 (UniProt - Evidence at protein level)

neXtProt

NX_Q96T58

Antibodypedia

SPEN antibodies
 

PROTEIN VIEW

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SPEN-001
 
SPEN-002
 
SPEN-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SPEN-001 ENSP00000364912
ENST00000375759
Q96T58
Show all »
Show » Show » 3664 402.2 No 0
SPEN-002 ENSP00000388021
ENST00000438066
F6WRY4
Show all »
Show » Show » 373 43 No 0
SPEN-004 ENSP00000400914
ENST00000442985
Show » Show » 297 32.9 No 0