PTBP1

GENE INFORMATION

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Gene name

PTBP1 (HGNC Symbol)

Synonyms

HNRNP-I, HNRPI, pPTB, PTB, PTB-1, PTB2, PTB3, PTB4

Description

Polypyrimidine tract binding protein 1 (HGNC Symbol)

Entrez gene summary

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

797075 - 812327

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000011304 (version 75.37)

Entrez gene

5725

UniProt

P26599 (UniProt - Evidence at protein level)

neXtProt

NX_P26599

Antibodypedia

PTBP1 antibodies
 

PROTEIN VIEW

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PTBP1-001
 
PTBP1-002
 
PTBP1-003
 
PTBP1-006
 
PTBP1-011
 
PTBP1-012
 
PTBP1-015
 
PTBP1-016
 
PTBP1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PTBP1-001 ENSP00000349428
ENST00000356948
P26599
Show all »
Show » Show » 557 59.6 No 0
PTBP1-002 ENSP00000408096
ENST00000394601
P26599
Show all »
Show » Show » 550 59 No 0
PTBP1-003 ENSP00000014112
ENST00000349038
P26599
Show all »
Show » Show » 531 57.2 No 0
PTBP1-006 ENSP00000465652
ENST00000589575
K7EKJ7
Show all »
Show » Show » 236 25.2 No 0
PTBP1-011 ENSP00000466250
ENST00000585535
K7ELW5
Show all »
Show » Show » 233 24.3 No 0
PTBP1-012 ENSP00000465825
ENST00000587094
K7EKX4
Show all »
Show » 56 5.7 No 0
PTBP1-015 ENSP00000468565
ENST00000586481
Show » Show » 253 26.9 No 0
PTBP1-016 ENSP00000465451
ENST00000585956
Show » Show » 256 27.1 No 0
PTBP1-201 ENSP00000342332
ENST00000350092
A6NLN1
Show all »
Show » Show » 197 21.9 No 0