TIMP2 - Gene info - The Human Protein Atlas

Gene name

TIMP2 (HGNC Symbol)

Synonyms

CSC-21K

Description

TIMP metallopeptidase inhibitor 2 (HGNC Symbol)

Entrez gene summary

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

q25.3

Chromosome location (bp)

76849059 - 76921469

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000035862 (version 75.37)

Entrez gene

7077

UniProt

P16035 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TIMP2-001

ENSP00000262768
ENST00000262768

P16035
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P16035 [Direct mapping]
Metalloproteinase inhibitor 2
B4DFW2 [Target identity:65%; Query identity:100%]
Metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2, isoform CRA_c; cDNA FLJ57920, highly similar to Metalloproteinase inhibitor 2
K7EL90 [Target identity:14%; Query identity:100%]
Protein LOC100653515

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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007417 [central nervous system development]
GO:0007568 [aging]
GO:0008047 [enzyme activator activity]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030426 [growth cone]
GO:0030814 [regulation of cAMP metabolic process]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034097 [response to cytokine stimulus]
GO:0042493 [response to drug]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043085 [positive regulation of catalytic activity]
GO:0043408 [regulation of MAPK cascade]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045664 [regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045861 [negative regulation of proteolysis]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0071310 [cellular response to organic substance]

220

24.4

Yes

TIMP2-002

ENSP00000464930
ENST00000592761

K7EIX4
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K7EIX4 [Target identity:100%; Query identity:100%]
Metalloproteinase inhibitor 2
K7EL90 [Target identity:29%; Query identity:100%]
Protein LOC100653515

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007417 [central nervous system development]
GO:0007568 [aging]
GO:0008047 [enzyme activator activity]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0030426 [growth cone]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034097 [response to cytokine stimulus]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045861 [negative regulation of proteolysis]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0071310 [cellular response to organic substance]

109

12.2

TIMP2-003

ENSP00000441724
ENST00000536189

B4DFW2
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B4DFW2 [Target identity:100%; Query identity:100%]
Metalloproteinase inhibitor 2; TIMP metallopeptidase inhibitor 2, isoform CRA_c; cDNA FLJ57920, highly similar to Metalloproteinase inhibitor 2
K7EL90 [Target identity:22%; Query identity:100%]
Protein LOC100653515

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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005604 [basement membrane]
GO:0005615 [extracellular space]
GO:0007417 [central nervous system development]
GO:0007568 [aging]
GO:0008047 [enzyme activator activity]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009986 [cell surface]
GO:0030426 [growth cone]
GO:0032487 [regulation of Rap protein signal transduction]
GO:0034097 [response to cytokine stimulus]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045762 [positive regulation of adenylate cyclase activity]
GO:0045861 [negative regulation of proteolysis]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0071310 [cellular response to organic substance]

143

16.1

TIMP2-004

ENSP00000468296
ENST00000586057

B4DFW2
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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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143

16.1

TIMP2-008

ENSP00000467584
ENST00000585421

B4DFW2
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Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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143

16.1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.