MSR1

GENE INFORMATION

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Gene name

MSR1 (HGNC Symbol)

Synonyms

CD204, SCARA1

Description

Macrophage scavenger receptor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p22

Chromosome location (bp)

15965387 - 16424999

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000038945 (version 75.37)

Entrez gene

4481

UniProt

P21757 (UniProt - Evidence at protein level)

neXtProt

NX_P21757

Antibodypedia

MSR1 antibodies
 

PROTEIN VIEW

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MSR1-001
 
MSR1-002
 
MSR1-003
 
MSR1-004
 
MSR1-005
 
MSR1-006
 
MSR1-007
 
MSR1-008
 
MSR1-201
 
MSR1-202
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MSR1-001 ENSP00000262101
ENST00000262101
P21757
Show all »
Show » Show » 451 49.8 No 1
MSR1-002 ENSP00000347430
ENST00000355282
P21757
Show all »
Show » Show » 388 42.9 No 1
MSR1-003 ENSP00000371428
ENST00000381998
P21757
Show all »
Show » Show » 358 39.6 No 1
MSR1-004 ENSP00000405453
ENST00000445506
B4DDJ5
Show all »
Show » Show » 469 51.7 No 1
MSR1-005 ENSP00000428865
ENST00000519060
E5RFI4
Show all »
Show » 37 4.4 No 0
MSR1-006 ENSP00000430536
ENST00000522672
H0YBY2
Show all »
Show » Show » 149 15.9 No 0
MSR1-007 ENSP00000429498
ENST00000518026
E5RI91
Show all »
Show » 58 6.5 No 0
MSR1-008 ENSP00000427905
ENST00000518960
E5RFW8
Show all »
Show » Show » 64 7.3 No 0
MSR1-201 ENSP00000262100
ENST00000350896
P21757
Show all »
Show » Show » 388 42.9 No 1
MSR1-202 ENSP00000444414
ENST00000536385
F5GZJ2
Show all »
Show » Show » 132 13.9 No 0