FMO4

GENE INFORMATION

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Gene name

FMO4 (HGNC Symbol)

Synonyms

FMO2

Description

Flavin containing monooxygenase 4 (HGNC Symbol)

Entrez gene summary

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. [provided by RefSeq, Sep 2013]

Chromosome

1

Cytoband

q24.3

Chromosome location (bp)

171283347 - 171311223

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000076258 (version 75.37)

Entrez gene

2329

UniProt

P31512 (UniProt - Evidence at transcript level)

neXtProt

NX_P31512

Antibodypedia

FMO4 antibodies
 

PROTEIN VIEW

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FMO4-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FMO4-001 ENSP00000356723
ENST00000367749
P31512
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