UBE2A

GENE INFORMATION

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Gene name

UBE2A (HGNC Symbol)

Synonyms

HHR6A, RAD6A, UBC2

Description

Ubiquitin-conjugating enzyme E2A (HGNC Symbol)

Entrez gene summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair, and may play a role in transcriptional regulation. Mutations in this gene are associated with mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Chromosome

X

Cytoband

q24

Chromosome location (bp)

118708501 - 118718381

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000077721 (version 75.37)

Entrez gene

7319

UniProt

P49459 (UniProt - Evidence at protein level)

neXtProt

NX_P49459

Antibodypedia

UBE2A antibodies
 

PROTEIN VIEW

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UBE2A-001
 
UBE2A-002
 
UBE2A-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

UBE2A-001 ENSP00000360613
ENST00000371558
P49459
Show all »
Show » Show » 152 17.3 No 0
UBE2A-002 ENSP00000335027
ENST00000346330
P49459
Show all »
Show » Show » 122 13.8 No 0
UBE2A-003 ENSP00000360624
ENST00000371569
P49459
Show all »
Show » Show » 77 8.8 No 0