REST

GENE INFORMATION

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Gene name

REST (HGNC Symbol)

Synonyms

NRSF, XBR

Description

RE1-silencing transcription factor (HGNC Symbol)

Entrez gene summary

This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described [provided by RefSeq, Jul 2010]

Chromosome

4

Cytoband

q12

Chromosome location (bp)

57774075 - 57802010

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000084093 (version 75.37)

Entrez gene

5978

UniProt

Q13127 (UniProt - Evidence at protein level)

neXtProt

NX_Q13127

Antibodypedia

REST antibodies
 

PROTEIN VIEW

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REST-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

REST-001 ENSP00000311816
ENST00000309042
Q13127
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